Despite the efficacy of IV tPA, the narrow therapeutic window precludes wide scale use of the therapy mainly because a large majority of patients arrive too late in the hospital. WHAT IS ENE CIR RECEIVER HP ACTIVATORThe only Food and Drug Administration approved medical therapy for stroke is intravenous tissue plasminogen activator (alteplase or IV tPA), which should be administered preferably as quickly as possible within 4 h 30 min ( 2). Additional research on imaging findings associated with recent stroke and penumbral imaging will eventually lead to a shift from a rigid time-frame based therapy to a tissue-based individualized treatment approach.Ībout one in six persons older than 45 will suffer from stroke in their remaining lifetime ( 1). The different imaging-selection criteria that can be used to treat these patients are discussed. We performed a meta-analysis of the diagnostic accuracy of the diffusion-FLAIR mismatch in identifying stroke within 3 and 4.5 h. We looked at the safety and efficacy of thrombolysis and interventional techniques in the group of patients with unknown stroke-onset. In this review, we assessed the current literature about the hypothesis that wake-up-strokes occur just prior on awakening and if this subgroup differs in characteristics compared to the overall stroke population. A large group of these patients might be eligible for therapy. Currently, this subset of patients is excluded from revascularization-therapy since no exact time of onset is known. Patients, who wake up with an ischemic stroke, account for a large number of the total stroke population, due to circadian morning predominance of stroke.
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